Acupuncture effect on cognitive improvement in patients with mild cognitive impairment

Neurocircuitry of acupuncture effect on cognitive improvement in patients with mild cognitive impairment using MRI

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0002896

Enrollment

Registered

2018-05-25

Start date

2018-07-18

Completion date

Unknown

Last updated

2019-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Medical Device : Subjects are randomly assigned to either acupuncture group or sham acupuncture group. In the acupuncture group, acupuncture penetrates the skin, whereas in the sham acupuncture group,

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients who meet the criteria for mild cognitive impairment (MCI) 2) Men and women aged 50 to 70 3) Suffering memory loss of more than 3 months 4) Education level of more than 6 years 5) a Korean-type Montreal Cognitive Assessment (MoCA-K) score < 23 6) a CDR (Clinical Dementia Rating) score of 0.5 and GDS (Global Deterioration Scale) grade 2-3 7) a Modified Hachinski Ischemic Score (HIS) score of 4 or less 8) Voluntarily signed the informed consent form

Exclusion criteria

Exclusion criteria: 1) Patients who meet the criteria for dementia of DSM-5 (Diagnostic and Statistical Manual of Mental Disorder) 2) Presenting cerbral lesions or brain damage 3) History of cerebral hemorrhage or cerebral infarction 4) Neurological disorderssuch as Parkinson's disease, epilepsy, brain tumor, and etc. 5) Mental disorder such as major depressive disorder, schizophrenia, bipolar disorder, and etc. 6) Participations in other clinical trials within the last 4 weeks 7) Receiving acupuncture treatments within the last 4 weeks due to cognitive impairment 8) Taking medications related to dementia 9) Pregnant or lactating women 10) Obstructive phobia or metal implantation 11) Patient who have experienced hypersensitivity reactions after acupuncture treatment, or who are difficult to cooperate with acupuncture treatment 12) Others judged inappropriate as subjects by researchers

Design outcomes

Primary

Measure	Time frame
Digit span test	—

Secondary

Measure	Time frame
Digit span test;Digit Symbol Substitution Test (DSST);Korean Version of Montreal Cognitive Assessment (MoCA-K);Seoul Neuropsychological Screening Battery-II (SNSB-II);Korean Beck Depression Inventory-II (BDI-II);State-Trait Anxiety Inventory (STAI);working memory task performance score;Brain activity change by working memory task performance;Brain activity change by emotional image stimulation;Changes of cerebral blood flow;Changes in functional and structural networks of the brain;Adverse events	—

Measure

Time frame

Digit span test;Digit Symbol Substitution Test (DSST);Korean Version of Montreal Cognitive Assessment (MoCA-K);Seoul Neuropsychological Screening Battery-II (SNSB-II);Korean Beck Depression Inventory-II (BDI-II);State-Trait Anxiety Inventory (STAI);working memory task performance score;Brain activity change by working memory task performance;Brain activity change by emotional image stimulation;Changes of cerebral blood flow;Changes in functional and structural networks of the brain;Adverse events

—

Countries

Korea, Republic of

Contacts

Public ContactSun-Yong Chung

Kyung Hee University Oriental Medicine Hospital at Gangdong

lovepwr@khnmc.or.kr+82-2-440-8568

Outcome results