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Investigation of uterine (cervical, endometrial) carcinogenesis by identifying multiple interaction [Host – HPV – Microbiome – Environment]

Investigation of uterine (cervical, endometrial) carcinogenesis by identifying multiple interaction of human uterine (cervical, endometrial) microbiome using Meta-Omics analysis [Host – HPV – Microbiome – Environment]

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0002854
Enrollment
1800
Registered
2018-05-09
Start date
2013-04-23
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

NCC Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Normal 1) 18 years of age or older 2) human papilloma virus(HPV)-negative women 3) had normal for final diagnosis 2. Cervix 1) 18 years of age or older with sexually active 2) human papilloma virus(HPV)-positive women 3) had normal or cervical intraepithelial neoplasia(CIN), cervical cancer 3. Endometrium 1) 18 years of age or older 2) women undergoing hysterectomy or curettage by any standard surgical approach 3) undergoing hysterectomy for benign disease, hyperplasia, or any stage of endometrial cancer

Exclusion criteria

Exclusion criteria: 1. Normal 1) under 18 years 2) had normal for final diagnosis, but human papilloma virus(HPV)-positive women 3) no written informed consent 2. Cervix 1) under 18 years 2) women who were pregnant or nursing 3) had history of hysterectomy or treatment for cervical intraepithelial neoplasia(CIN) or cervical cancer during the 18 months previous to enrollment 4) no written informed consent 3. Endometrium 1) under 18 years 2) women who were pregnant or nursing 3) had taken antibiotics within two weeks preceding surgery 4) surgeon using morcellation during the hysterectomy procedure, due to the size of the uterus or for any other reason 5) no written informed consent

Design outcomes

Primary

MeasureTime frame
Association of dietary glycemic index(GI) with risk of cervical intraepithelial neoplasia(CIN) (odd ratio and 95% confidence interval);Association of dietary glycemic index(GI) with risk of cervical cancer (odd ratio and 95% confidence interval);Association of dietary glycemic load(GL) with risk of cervical intraepithelial neoplasia(CIN) (odd ratio and 95% confidence interval);Association of dietary glycemic load(GL) with risk of cervical cancer (odd ratio and 95% confidence interval)

Secondary

MeasureTime frame
Association of human papillomavirus(HPV) infection with risk of cervical intraepithelial neoplasia(CIN) (odd ratio and 95% confidence interval);Association of human papillomavirus(HPV) infection with risk of cervical cancer (odd ratio and 95% confidence interval)

Countries

Korea, Republic of

Contacts

Public ContactMi Kyung Kim

NCC Hospital

alrud@ncc.re.kr+82-31-920-2202

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026