The evaluation of clinical effect of locally delivered minocycline hydrochloride in the surgical treatment of peri-implantitis

The evaluation of clinical effect of locally delivered minocycline hydrochloride in the surgical treatment of peri-implantitis: a randomized clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0002844

Enrollment

Registered

2018-05-04

Start date

2016-12-05

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : 1. Test Group Generic name / Product name: Minocyclicline hydrochloride / Periocline Dental Ointment Method: Inject test substance into the pockets formed by periodontal pathogen around peri-i

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The following inclusion criteria were applied: - Diagnostic criteria of peri-implantitis; peri-implant bone loss > 2mm, probing depth > 5mm, bleeding on probing/suppuration and presence of plaque (Lang et al. 2004) - No history of active (surgical) treatment for peri-implantitis - Bone loss that occurred apical to the reference point established based on implant system when there is no radiographic data that can be used as the baseline The reference points according to the implant system are as follows: Branemark type: First thread Straumann type: 2.8mm(standard) / 1.8mm(standard plus) below the implant shoulder Astra tech type: 1.8mm below the implant shoulder Reference) Effectiveness of Implant Therapy Analyzed in a Swedish Population: Prevalence of Peri-implantitis. Derks J, Schaller D, Håkansson J, Wennström JL, Tomasi C, Berglundh T.J Dent Res. 2016 Jan;95(1):43-9.

Exclusion criteria

Exclusion criteria: The following exclusion criteria were applied: - Presence of pregnancy or lactation. - Taking drugs that can affect periodontal disease (phenytoin, cyclosporine, and calcium channel blockers). - Taking Coumadin or non-steroidal anti-inflammatory drugs. - Presence of diabetes mellitus, smoking (except former smoking with cessation at least 10 - Those who is allergies with tetracycline. - Those using chlorhexidine or any other mouth rinse. - Those who have taken antibiotics within the previous 3 months.

Design outcomes

Primary

Measure	Time frame
Probing Depth	—

Secondary

Measure	Time frame
Bleeding on probing,;Plaque index;Bacterial analysis	—

Countries

Korea, Republic of

Contacts

Public ContactTae-Hwan Koo

Yonsei University Health System, Dental Hospital

kooth1049@naver.com+82-2-2228-8825

Outcome results