Investigation of the brain pathophysiology of addiction disorder and evaluation of the treatment effect of neuromodulation

Investigation of the brain pathophysiology of addiction disorder using cerebral glucose metabolism and brain network analysis and evaluation of the treatment effect of neuromodulation

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0002823

Enrollment

Registered

2018-04-23

Start date

2018-03-22

Completion date

Unknown

Last updated

2019-07-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug, Medical Device : (1) Active transcranial direct current stimulation for patients with alcohol use disorder: standard psychiatric drug treatment for alcohol use disorder and transcranial direct c

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: [Alcohol use disorder group] (a) Diagnosed with alcohol use disorder based on the Diagnostic and Statistical Manual of Mental Disorders-5 and taking standard medication, and alcohol abstinence status will be considered. (b) Adult men and women aged 20 to 60 years [Problematic drinking group] (a) More than 4 standard drinks (SD) for one occasion or more than 14 SD for one week (men) / More than 3 SD for one occasion or more than 7 SD for one week (women) or scores of 8 or more on Alcohol Use Disorders Identification Test (AUDIT) for men / scores of 6 of more on AUDIT for women (b) Adult men and women aged 20 to 60 years [Normal control group] (a) Adult men and women aged 20 to 60 years

Exclusion criteria

Exclusion criteria: Exclusion criteria (a) Have major medical, neurological, or psychiatric illnesses (b) Pregnant, lactation, or have a pregnancy plan (c) Not compatible for MRI and PET-CT (internal metal and medical devices, claustrophobia, etc.) (d) History of seizures (e) Problems with stimulation electrodes due to deformity of the scalp, inflammation reaction or other dermatological problems (f) History of cancer in the past three years (g) Surgery for brain vessels such as brain surgery or carotid surgery (h) Dyspnea when sitting still (i) Loss of consciousness for more than one hour due to other causes other than general anesthesia (j) Have been hospitalized for a head injury

Design outcomes

Primary

Measure	Time frame
Alcohol use disorder symptoms such as cravings assessed by self-report questionnaire;Maintenance of abstinence from alcohol	—

Secondary

Measure	Time frame
Changes in structure, function, and metabolism of the brain evaluated using MRI and PET;Changes in depressive symptoms assessed by self-report questionnaire;Changes in anxiety symptoms assessed by self-report questionnaire;Changes in cognitive function evaluated by neuropsychological tests	—

Countries

Korea, Republic of

Contacts

Public ContactHyeonseok Jeong

The Catholic University of Korea, Incheon St. Mary's Hospital

hyeonseok.s.jeong@gmail.com+82-32-280-5254

Outcome results