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Efficacy of fixed monthly dosing of Lucentis® (Ranibizumab) on subretinal fluid associated with persistent retinal pigment epithelial detachment in neovascular age-related macular degeneration: An exploratory study

Efficacy of fixed monthly dosing of Lucentis® (Ranibizumab) on subretinal fluid associated with persistent retinal pigment epithelial detachment in neovascular age-related macular degeneration: An exploratory study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CRIS
Registry ID
KCT0002804
Enrollment
20
Registered
2018-04-18
Start date
2016-03-03
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : All patients received intravitreal injection of ranibizumab (0.5mg/0.05ml) according to the fixed dosing regimen, which treated with baseline injection followed by five sequential injections at

Sponsors

Seoul National University Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. age older than 50 years 2. known choroidal neovascularization secondary to age related macular degeneration as demonstrated by fluorescein angiography 3. persistent pigment epithelial defect (with possible serous component) and subretinal fluid due to choroidal neovascularization

Exclusion criteria

Exclusion criteria: 1. history of previous vitrectomy 2. prior photodynamic treatment and/or photocoagulation on macular region 3. patients had other retinal conditions other than typical AMD 4. previous history of systemic of ocular corticosteroid medication 5. active intraocular inflammation or systemic infection.

Design outcomes

Primary

MeasureTime frame
Changes in volume and maxium heigh of subretinal fluide and pigment epithelial defect;Changes of visula acuity and central macular thickness

Secondary

MeasureTime frame
Analysis of factors affecting therapeutic response

Countries

Korea, Republic of

Contacts

Public ContactIn Hwan Hong

Seoul National University Hospital

loperter@hanmail.net+82-2-2072-3110

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026