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Effect of adding dexmedetomidine in epidural analgesia after thoracotomy surgery

Effect of adding dexmedetomidine in epidural analgesia after thoracotomy surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CRIS
Registry ID
KCT0002787
Enrollment
44
Registered
2018-04-11
Start date
2017-03-13
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Forty four patients aged &gt
19 years with an American Society of Anesthesiologists (ASA) physical status of I-III were scheduled open thoracotomy for lung cancer or other lung disease, and to be sedative care postoperatively in
lidocaine 3 mL) + epinephrine 15 µg was injected through the catheter and confirmed no hemodynamic changes or neurological changes. After endotracheal intubation, a loading dose of 50 µg fentanyl + le
levobupivacaine 7.5 mL) was injected via the pre-placed epidural catheter. For patient controlled-epidural analgesia (PCEA), a total volume of 150 ml (levobupivacaine 300 mg + fentanyl 500 µg) was inf
levobupivacaine at 1 mL/h plus a bolus dose of 3 mL with a lockout time of 30 min through the epidural catheter. Before 30 minutes at the end of surgery, group D was injected with 0.3 µg/kg /h of dexm

Sponsors

Pusan National University Yangsan Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Forty-four patients aged more than 19 years , with an American Society of Anesthesiologists (ASA) physical status of I-III, scheduled to undergo open thoracotomy

Exclusion criteria

Exclusion criteria: Patients with neurologic, mental dysfunction, patients with impaired kidney and liver function, patients with impaired heart function or circulation, patients with drug abuse, allergic reaction to dexmedetomidine or levobupivacaine, patients with neurologic deficit, bleeding tendency, infectious state at thorax, pregnancy

Design outcomes

Primary

MeasureTime frame
Visual analogue scale (VAS)

Secondary

MeasureTime frame
Patient sedation;consumed dose of patient controlled analgesic drugs;blood pressure and heart rate;amount and number of patients requiring additional analgesics;adverse events;patients satisfaction for pain management;change of PaCO2, PaO2, and O2 saturation

Countries

Korea, Republic of

Contacts

Public ContactGyeong-Jo Byeon

Pusan National University Yangsan Hospital

cooki1713@naver.com+82-55-360-2758

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026