None listed
Conditions
Interventions
Dietary Supplement : 1) Thromboelastography (ROTEM®)
In order to investigate whether ascorbic acid has an effect on the platelet function during cardiac surgery, we first performed thromboelastograph
normal saline).
2) Washed platelet preparation
At the same time as performing thromboelastography, 11 mL of fresh blood was collected from arterial catheter placed in the right radial artery and div
3.6 mL of fresh blood
N group
normal saline
A group
normal saline
Sponsors
Samsung Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Recipients who underwent cardiac surgery using cardio-pulmonary bypass at our hospital, a university-affiliated hospital, were enrolled into this study.
Exclusion criteria
Exclusion criteria: A. severe heart failure ( ejection fraction < 30% ) B. repeated cardiac surgery C. patients who received platelet concentrates within 7 days and during operation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thromboelastography (ROTEM®) : CT (coagulation time), CFT (clot formation time), alpha-angle, MCF (maximum clot firmness), LI60 (lysis index 60 min after CT), ML (maximum lysis) and AUC (area under the curve) | — |
Secondary
| Measure | Time frame |
|---|---|
| Washed platelet preparation and Immunoblottings ( to evaluate effect of ascorbic acid on c-Cbl and Cbl-b ) | — |
Countries
Korea, Republic of
Contacts
Public ContactJi-hye Kwon
Samsung Medical Center
Outcome results
None listed