None listed
Conditions
Interventions
Medical Device : Subjects receive instructional education about tDCS and evaluation before trial.
Those who pass the evaluation can receive the tDCS device.
Either active or sham tDCS is applied at
Sponsors
Yonsei University Health System, Severance Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Adults with the age of 60 or more, but less than 80 (based on resident registration number) 2) Those with subjective memory impairment while maintaining normal general functions and daily life performance 3) Declined cognitive function suggested by Korean Version of the Mini–Mental State Examination for Dementia Screening(MMSE-DS) 4) Seoul-Instrumental Activities of Daily living score 7 or below 5) Korean version of Global Deterioration Scale (GDS) score of 2~3 or Clinical Dementia Rating(CDR) score of 0.5 assessed by the clinician 6) Korean version of Geriatric depression scale(K-GDS) score 8 or below
Exclusion criteria
Exclusion criteria: 1) A person who was diagnosed with the Alzheimer's disease or is currently taking cognitive enhancer such as donepezil, rivastigmine, galantamine, or memantine 2) History of intellectual disability 3) Medical history that can cause cognitive dysfunction 4) A person who is currently diagnosed with alcohol dependence using Diagnostic and Statistical Manual of Mental Disorders 4th edition(DSM-IV) 5) History of seizure 6) A person who suffers from serious dysfunction in cardiovascular, digestive, respiratory, endocrine or central nervous systems 7) A person who received cerebrovascular surgery including brain and carotid artery 8) A person who seems to have a problem with attaching the electrodes due to scalp deformity, inflammatory reaction, or other dermatological reasons 9) A person who is prohibited from applying transcranial direct current stimulation device with other reasons such as a metal plate inserted in cephalic region 10) A person who participated in other clinical trials within 30 days from screening 11) A person who wears glasses, but still are unable to read the ordinary writings because of the visual problem 12) A person who uses the hearing aid, but still has difficulty in understanding the conversation because of the auditory problem 13) Apart from as mentioned above, person with any disqualifying clinical problem determined by the investigator * Patients who take medication for psychiatric treatment or internal disease treatment can be included
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual recognition task | — |
Secondary
| Measure | Time frame |
|---|---|
| Letter- Number Sequencing;Spatial Span;Clinical Global Impression;Neuropsychiatric Inventory;The Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery | — |
Countries
Korea, Republic of
Contacts
Public ContactYoonkyung Oh
Yonsei University Health System, Gangnam Severance Hospital
Outcome results
None listed