None listed
Conditions
Interventions
None listed
Sponsors
Korea Institute of Oriental Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) Women aged 20 to 65 years 2) The Korean Hamilton Depression Rating Scale score is less than 7 3) Those who can make sufficient communication and questionnaire 4) Decide on voluntary participation and sign the written agreement
Exclusion criteria
Exclusion criteria: 1) People with a medical condition that may affect the degree of depression (eg, myocardial infarction, brain tumor, multiple sclerosis, hyperthyroidism, hyperparathyroidism, Addison's disease, Cushing's disease, rheumatoid arthritis, Vascular disease, epilepsy, etc.) 2) Those who have undergone medical surgery or treatment within 1 month of the start of clinical research 3) Those who have had acute and chronic infectious diseases for the last 2 weeks 4) Those who had excessive diet control for disease-related or weight control purposes within one week of the start of clinical studies 5) Those who are taking periodical medicines by internal medicine, surgery, psychiatric diagnosis at the time of starting the clinical study, and those who are thought to be able to influence the autonomic nervous system and depressive symptom manifestations (eg anxiolytics, antidepressants, L-dopa, Digitalis, bromide, cyclosporin, disulfiram, isoniazid, yohimbine, etc.) 6) Those who have been diagnosed with medical or psychiatric disorders and have not been informed about clinical symptoms or biochemical indicators 7) Those with chronic diseases that are not well controlled by appropriate treatment (chronic active hepatitis, hypertension, diabetes, etc.) 8) Those who are treated with liver cancer or liver cirrhosis, chronic renal failure, congestive heart failure, etc. 9) Those who are pregnant or are pregnant or are lactating 10) AST or ALT exceeds 2 times the upper limit of the reference range, or Total Bilirubin exceeds 2 times the upper limit of the reference range 11) Patients with renal impairment (Cockcroft-Gault-type creatinine clearance less than 50 mL / min 12) Alcohol or other substance Abuse / Dependence or history 13) Those who participated in other clinical studies with intervention within one month before the start of the study 14) Those who do not understand the consent because of mental retardation and intellectual problems, or are unable to continue the research 15) Those who have communication difficulties that are difficult to follow the directions of the researcher 16) Any other person who is considered to be ineligible to take the test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Korean Hamilton Depression Rating Scale(K-HDRS);The Korean version of the Beck Depression Inventory(BDI-K);Pattern identifications tool for Depression;Korean Symptom Checklist-95 (KSCL-95);Insomnia Severity Index (ISI);State-Trait Anxiety Inventory;EuroQol-5 dimension (EQ-5D);Revised "Neuroticism, Extraversion, Openness to experience" Personality Inventory(NEO-PI-R);Emotional Stimulus Test;Brain-derived neurotrophic factor (BDNF);Inflammatory cytokines and tumor necrosis factor (IL-1ß, IL-2, IL-4, IL-6, IL-10, TNF-a, IFN-?, TGF-ß1);Depression-related genetic polymorphism & Epigenetic test (SLC6A4, SLC6A3, SLC1A1, GAD1, NR2A, NRG1, TPH2, GRM7, OXTR, AVPR1A, MGLUR5, COMT, BDNF, IL6, IL1beta);microbiome;Diet report | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction | — |
Countries
Korea, Republic of
Contacts
Public ContactKim Hwan
Dunsan Korean Medicine Hospital of Daejeon University
Outcome results
None listed