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The effect of combination of palonosetron and aprepitant for the prevention of postoperative nausea and vomiting in women patients using intravenous patient-controlled analgesia: combination of palonosetron and aprepitant vs palonosetron alone.

The effect of combination of palonosetron and aprepitant for the prevention of postoperative nausea and vomiting in women patients using intravenous patient-controlled analgesia: combination of palonosetron and aprepitant vs palonosetron alone.

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CRIS
Registry ID
KCT0002433
Enrollment
100
Registered
2017-08-28
Start date
2013-08-01
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : P group
receive 0.075 mg of palonosetron i.v. after induction of anesthesia AP group
receive 80mg of aprepitant P.O. 2-3 hours before the operation + 0.075 mg of palonosetron i.v. after induction of anesthesia

Sponsors

Soon Chun Hyang University Hospital Seoul
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Healthy adult woman who is undergoing elective surgery under general anesthesia, and received intravenous patient-controlled analgesia using fentanyl for postoperative pain control

Exclusion criteria

Exclusion criteria: The patients with respiratory, cardiovascular, gastrointestinal, cerebral, renal, or hepatic disease. The patients who experienced nausea and vomiting within 24 hours before surgery. The patients who received antiemetics or steroids within 24 hours before surgery. pregnant woman, severe obese

Design outcomes

Secondary

MeasureTime frame
Nausea severity, rescue antiemetics use, patients' satisfaction and adverse effects during 24 hours after operation—

Primary

MeasureTime frame
The incidence of nausea and vomiting during the 24 hours after operation.—

Countries

Korea, Republic of

Contacts

Public ContactSoon Im Kim

Soon Chun Hyang University

anesikim@gmail.com+82-2-709-9294

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026