None listed
Conditions
Interventions
Drug : Group N: Normal saline 10 mL intravenous injection
Group S: hydrocortisone 100 mg + normal saline 10 mL intravenous injection
Hydrocortisone 100 mg is a commonly used concentration for stress d
Sponsors
Seoul National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The patients with nonfunctional pituitary adenomas scheduled for TSA surgery at 8 am at the Seoul National University Hospital, whose morning cortisol levels were normal (over 5 ug / dL) or insulin tolerance test or rapid ACTH test (peak> 18ug / DL).
Exclusion criteria
Exclusion criteria: ? functional pituitary tumor ? pituitary apoplexy ? steroid users within the last 3 months ? steroid treatment for other reasons during surgery (cerebral edema, visual loss, airway edema, nausea / vomiting, minimal residual gland visualized) ? taking drugs affecting the HPA axis (oral pill, etomidate, ketoconazole, metyrapone, mitotane, tyrosine kinase inhibitors, megestrol, anticoagulants) ? previous brain or adrenal gland operation history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum cortisol level | — |
Secondary
| Measure | Time frame |
|---|---|
| serum ACTH level;serum glucose level;cardiovarcular collapse (SBP < 80mmHg or HR > 120 or HR < 40) incidence, duration;steroid treatment and cause;steroid dependency | — |
Countries
Korea, Republic of
Contacts
Public ContactHyung-Chul Lee
Seoul National University Hospital
Outcome results
None listed