None listed
Conditions
Interventions
Drug : In patients in whom asthma is well controlled by inhaled steroids alone (ICS) for more than 6 months, the inhaled steroid therapy group (fluticasone = 250 µg / day or budesonide = 400 µg / day
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) aged over 18 years 2) physician-diagnosed asthma 3) an evidence of reversible airway obstruction with positive bronchodilator response [>12% improvement in percentage of forced expiratory volume in 1 sec(FEV1) and at least 200 ml after inhalation of 180 mg of albuterol] or an airway hyper-responsiveness with positive methacholine bronchial provocation test [provocative concentration of methacholine causing a 20% reduction in FEV1=16 mg/mL] or FEV1 variability of greater than 15% during outpatient visit and 4) FEV1 greater than 70% of expected value.
Exclusion criteria
Exclusion criteria: Exclusion criteria included any of followings; cigarette smoking more than 10 pack-years, history of pulmonary tuberculosis with aftereffect, bronchiectasis or emphysema in chest X-ray, patients who are about to start immunotherapy and who take any kind of immunomodulatory like systemic corticosteroid, leukotriene modifier, theophylline and tiotropium.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome variables included changes of pre-bronchodilator FEV1 predicted percentage, Asthma symptom score (ACT) scores, Fractional exhaled nitric oxide(FeNO) and quality of life questionnaire for adult Korean asthmatics(QLQAKA) scores from baseline visit to loss of control time | — |
Primary
| Measure | Time frame |
|---|---|
| The time to loss of control (weeks) | — |
Countries
Korea, Republic of
Contacts
Public ContactJung-hyun Kim
Asan Medical Center
Outcome results
None listed