None listed
Conditions
Interventions
Dietary Supplement : Orostachydis Herba group receive 1g of Orostachydis Herba extracts, once a day, for 8 weeks. Placebo group receive 1g of dextrin, once a day, for 8 weeks.
Sponsors
Pusan National University Korean Medicine Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) adult male and female over the age of 45 (2) Those who can visit for follow up while study period, and can have examination which measured in this study including the blood collection (3) Those who decided to voluntarily participate in this clinical trial, and signed research agreement(informed consent)
Exclusion criteria
Exclusion criteria: (1) Those with diseases or conditions that may affect the immune system (Ex: Infectious diseases, autoimmune diseases, blood diseases, malignant neoplasms, such as distinct malnutrition) (2) Those who took drug that may affect the immune system (Ex: steroid, hormone) or may affect absorption, metabolism and excretion of trial food within a month recently. (3) Those with gastrointestinal diseases, operation (except for a simple appendectomy surgery or hernia surgery) which may affect absorption of trial food (4) Those with hypersensitivity reactions or side effects on Orostachydis Herba or similar plants (5) Those who intake Excessive alcohol - Male: more than 168g/week (about 3.5bottles/week as soju(Korean distilled spirits), about 12bottles/week as beer) - Female: more than 112g/week (about 2.3bottles/week as soju(Korean distilled spirits), about 8bottles/week as beer) (6) Pregnant women, nursing mothers and fertile women not using adequate contraception. (7) Those deemed inappropriate to participate this clinical trial by research personnel or research director, due to other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ratio of NK cell(percentage of NK cell among lymphocyte);The ratio of T-helper cell and T-suppressor cell(percentage of CD4+/CD8+ T cell) | — |
Secondary
| Measure | Time frame |
|---|---|
| Total numbers of Blood leukocytes(WBC);The ratio of neutrophil, lymphocyte, monocyte among leukocyte;The ratio of T cell, T-helper cell, T-suppressor cell, B cell among Lymphocytes;amount of blood IgM, IgG, IgA, CMV IgG;blood metabolome analysis target & gobal analysis (LC/MS) | — |
Countries
Korea, Republic of
Contacts
Public ContactJinyong Choi
Pusan National University Korean Medicine Hospital
Outcome results
None listed