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WT1 expression as an early predictor for molecular relapse in patients with acute promyelocytic leukemia in first remission with negative PML-RARa after anthracycline-based chemotherapy plus all-trans retinoic acid

igh post-remission WT1 expression is a predictive marker for subsequent molecular relapse and poor survival in adult patients with acute promyelocytic leukemia (APL)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0002079
Enrollment
117
Registered
2016-09-29
Start date
2015-12-14
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

The Catholic University of Korea, Seoul St. Mary's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) 18 years and older 2) Acute promyelocytic leukemia confirmed by t(15;17) karyotype or molecular marker such as PML-RARa 3) Acute promyelocytic leukemia in first hematological remission after induction chemotherapy followed by at least 2 consolidation chemotherapy 4) Patients with available WT1 expression results until 6 months after finishing last consolidation therapy

Exclusion criteria

Exclusion criteria: 1) Under 18 years old 2) Hematological malignancies without an evidence of t(15;17) karyotype or molecular marker such as PML-RARa 3) Acute promyelocytic leukemia in treatment failure after induction chemotherapy 4) Patients without available WT1 expression results

Design outcomes

Primary

MeasureTime frame
Cumulative incidence of relapse—

Secondary

MeasureTime frame
Disease free survival;Overall survival;multivariately analyzed affecting factors—

Countries

Korea, Republic of

Contacts

Public ContactJae-Ho Yoon

The Catholic University of Korea, Seoul St. Mary's Hospital

royoon@naver.com+82-2-2258-6270

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Mar 11, 2026