Pharmacodynamics of rocuronium in children

Pharmacodynamic modeling of rocuronium in children taking antiepileptic drugs – comparison with normal children

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0002074

Enrollment

Registered

2016-09-23

Start date

2016-09-26

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : 1. Rocuronium 2. Target controlled infusion 3. target effect site concentration of rocuronium = 100, 200, 400, 800, 1600, 3000ng/ml 4. Measure recovery index(From the start of rocuronium infu

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - American Society of Anesthesiologists physical status I, II - Planned for non-cardiac surgery under general anesthesia with an estimated operation time longer than 90 minutes

Exclusion criteria

Exclusion criteria: - History of drug allergy or anaphylaxis - Medications other than antiepileptic drugs - Myasthenia gravis, myasthenic syndrome, or neuromuscular diseases - Severe cardiovascular, pulmonary, hepatobiliary, renal diseases - Body mass index over 35 - Burn injury - Intraoperative hypothermia (37.5 celcius)

Design outcomes

Primary

Measure	Time frame
Recovery index	—

Secondary

Measure	Time frame
Onset time;Recovery time;Total dose of rocuronium	—

Countries

Korea, Republic of

Contacts

Public ContactHee-Soo Kim

Seoul National University Hospital

goingridgo@gmail.com

Outcome results