None listed
Conditions
Interventions
Dietary Supplement : study material: Capsule that contains the extract of Solidago virgaurea subsp. Gigantea
Taking 2 capsules/time, 3 times/ day with sufficient water.duration: 1
Sponsors
Hallym University Medical Center- Chuncheon
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subject who voluntarily agree to participate and signs informed consent form 2) 20 years= Age <65 years 3) 25kg/m2= body mass index> < 30kg/m2 4) 90 cm (male), 85 cm (female) = Waist circumference 5) Subject who can comply with dietary/exercise guidelines for intervention period
Exclusion criteria
Exclusion criteria: 1) Administration of medicine that affect body weight, metabolism of blood glucose, inflammatory response within 6 weeks of first visit. : Appetite suppressants/accelerators, diuretics, beta-blocker, contraceptive, steroid drug, tricyclic antidepressant, postmenopausal hormone medicine, laxatives, antidepressant, anti-inflammatory agent et al 2) Experience of commercial obesity program or calorie-restricted therapy within three months before the first visit 3) Consistent consumption of dietary supplements, oriental medicine or drug for body weight control or medication related with hepatic cirrhosis or hepatitis within one month before the first visit. 4) Subject with change of body weight more than 3kg within three months before the first visit 5) Subject with experience of Gastroplasty or intestinal resection for management body weight 6) Subject with experience of severe depression (in case of hospitalization or suicidal attempt) 7) Subject with experience of epilepsy or eating disorder 8) Subject with following diseases: ? Hypertension (Systolic blood pressure=140 mmHg or diastolic blood pressure =100 mmHg) ? Diabetes (use of hypoglycemic drug or fasting blood glucose= 180mg/dl) ? Liver dysfunction (Alanine transaminase or Aspartate Aminotransferase > 80 IU/L) ? Renal dysfunction (creatinine > 1.2 mg/dL) ? Hyperthyroidism or hypothyroidism ? Malignant tumor, heart disease, Cushing's disease, tuberculosis 9) Subjects with hypersensitivity to the test food/placebo or their component or experience of severe food allergy 10) Participation in other human study within one month before the first visit 11) Pregnant or lactating women 12) Subject with difficulty of using smart phone 13) Any condition that the principal investigator believes may put the subjects at undue risk
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Level of blood lipid(triglyceride, total cholesterol, HDL-cholesterol, and LDL-cholesterol), and insulin resistence markers(fasting blood glocose, insulin, and HOMA-IR );markers related with lipid metabolism (leptin, and adiponectin), and inflammatory markers (CRP, TNF-a, IL-6);Gene expression related with body fat, metabolism of blood glucose and inflammatory response. | — |
Primary
| Measure | Time frame |
|---|---|
| Area of abdominal fat, body composition ;Anthropometry (body weight, BMI, WC, and waist to hip ratio) | — |
Countries
Korea, Republic of
Contacts
Public ContactJeong-Hyeon Kim
Hallym University Medical Center- Chuncheon
Outcome results
None listed