None listed
Conditions
Interventions
Procedure/Surgery : Autologous serum aseptically seperated from the autologous blood or salinie will be administered to the patients by intramuscular injection, twice a week for 4 weeks (total 8 injec
Sponsors
Ajou University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult patients with recalcitrant atopic dermatitis (age = 13 years) whose clinical conditions has not been effectively controlled by current standard medical therapies for more than 2 months 2. =10% lesion body surface area (BSA) of atopic dermatitis involvement in area at the screening and baseline visits
Exclusion criteria
Exclusion criteria: Exclusion criteria 1) Patients under the age of 13 year. 2) Patients who are unable to agree on their own (emergency patients, patients with mental disability, patients with limited capacity to consent due to stroke or delirium caused by diabetes). 3) Patients with severe disease whose expected survival duration is less than 3 months. 4) Pregnancy or planned pregnancy within 1 year 5) Skin condition not appropriate for blood sampling and transfusion 6) Presence of skin comorbidities that may interfere with study assessments
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with both a reduction of clinical severity scores by = 30% or =50% from baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety verification;Blood test parameters (serum immunoglobulin, allergen-specific IgE, IgG autoantibodies, serum eosinophil cationic protein, cytokine, etc);Requirement for medication;Quality of life measured before and after the treatment | — |
Countries
Korea, Republic of
Contacts
Public ContactMyoung-Eun Kim
Ajou University Hospital
Outcome results
None listed