Preventive effect of ketamine on postsurgical widespread increase of pain sensitivity

Preventative effect of ketamine on post-surgical hyperalgesia induced at a body part remote from the surgical site: A radonmized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0001822

Enrollment

Registered

2016-02-19

Start date

2016-03-01

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Ketamin group: ketamine 1mg/kg ivs at induction of anesthesia and 0.5mg/kg/hr during the surgery. Control group: the same amount of normal saline is administered.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: aged 20-65 years, American society of Anesthesiologits physical status 1-2, patients undergoing total laparoscopic hysterectomy.

Exclusion criteria

Exclusion criteria: severe cardiac/hepatic/renal disease, increased intracranial/ocular pressure, pre-existing severe pain, chronic opioid use, psychiatric disorder, pre-existing hallucination/delirium/dementia, and allergy to study medications, male

Design outcomes

Primary

Measure	Time frame
postoperative mechanical pain threshold	—

Secondary

Measure	Time frame
postoperative visual analogue scale at rest;preoperative mechanical pain threshold;Visual analogue scale scores during deep breathing;consumption of analgesia;consumption of antiemetics;incidence of dizziness	—

Countries

Korea, Republic of

Contacts

Public ContactMi-Hyun Kim

The Catholic University of Korea, Seoul St. Mary's Hospital

ehdal34@gmail.com+82-2-2258-2263

Outcome results