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Comparison of age-differentiated incidence of sympathetic stimulation effect from rapid increases in desflurane concentration during induction of anesthesia with propofol and remifentanil; prospective randomized single-blind clinical investigation

Comparison of age-differentiated incidence of sympathetic stimulation effect from rapid increases in desflurane concentration during induction of anesthesia with propofol and remifentanil; prospective randomized single-blind clinical investigation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CRIS
Registry ID
KCT0001813
Enrollment
400
Registered
2016-02-12
Start date
2015-09-16
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Hemodynamic responses to anesthesia induction agents, that are inhalation agents, sevoflurane for active comparator group and desflurane for experimantal group, which are to be used with remife

Sponsors

Yonsei University Health System, Severance Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients, who are aged 20-59 years and to be scheduled for spine surgery in Severance Hospital, Seoul, Republic of Korea, are to be recruited.

Exclusion criteria

Exclusion criteria: Patients who are anticipated to have difficulty for endotracheal intubation, presenting with upper respiratory infection or asthma, have a comorbidity of cardiovascular, cerebrovascular or neuronal, renal or endocrinologic abnormality, and are diagnosed with metastatic cancer, except for patients with well-controlled hypertension or diabetes with oral agents. Vulnerable subjects, such as pregnant women, illiteracy or foreigners, are also excluded.

Design outcomes

Primary

MeasureTime frame
heart rate

Secondary

MeasureTime frame
Arterial blood pressure - systolic, diastolic and mean

Countries

Korea, Republic of

Contacts

Public ContactJong Wha Lee

Yonsei University Health System, Severance Hospital

jhanes@yuhs.ac+82-2-2228-8516

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026