None listed
Conditions
Interventions
Procedure/Surgery : Patients received an initial intravenous bolus of propofol 2.0 mg/kg. Time to loss of consciousness (LOC) was determined every 5 s by the loss of response to verbal command. After
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 20 yr < age <65 yr 2. BMI (body mass index) < 18.5 (kg/m2) 3. Hemoglobin > 9 g/dl 4. Patients who signed a written informed consent form
Exclusion criteria
Exclusion criteria: 1-1. Patients with severely impaired respiratory function or respiratory depression status 1-2. Patients with convulsive disorders, head injury, shock, a reduced level of consciousness of uncertain origin, intracranial lesions or increased intracranial pressure, or in patients with severe hepatic impairment 1-3. Patients who are concurrently taking other CNS depressants that may cause respiratory depression, hypotension, profound sedation or potentially result in coma 1-4. Clinically significant impairment of cardiovascular, respiratory and renal function 2. Patients with known hypersensitivity to intervention treatments (propofol) or to any of the excipients 3. Patients who are considered by the investigator to be unsuitable to participate in the study for any other reason not mentioned in the inclusion and exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| voluem of distribution, clearance | — |
Secondary
| Measure | Time frame |
|---|---|
| Area ynder the curve | — |
Countries
Korea, Republic of
Contacts
Public ContactByungmoon Choi
Asan Medical Center
Outcome results
None listed