None listed
Conditions
Interventions
Dietary Supplement : Subjects were randomly allocated to placebo group or Cynanchum wilfordii extract group (low dose or high dose). Then subjects consume palcebo or Cynanchum wilfordii extract once a
Sponsors
Seoul National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subject who voluntarily agrees to participate and sign in informed consent form 2) Adults (20 years = Age, both male and female) 3) 18 kg/m2 = BMI (Body Mass Index) = 30 kg/m2 4) Fasting blood LDL-cholesterol level = 130 mg/dL 5) Fasting blood triglyceride level< 300 mg/dL
Exclusion criteria
Exclusion criteria: 1) Fasting blood LDL-cholesterol level = 190mg/dL 2) Subjects who had consistently consumed the drug related to lipid metabolism (ex. statin, diuretics, beta blocker.. etc.) or inflammation metabolism within 4 weeks before the first visit. The subject who have taken thiazide and beta blockers among the diuretics without change of dose during last one year and expected not to change the dosage during the study period. 3) Subjects who consumed the functional food or food related to lipid metabolism or inflammation within 4 weeks before the first visit (example: plantsterol, w-3 fatty acid, aloe, chitosan, onion extract. etc.) 4) Subjects who are controlling body weight or subjects who have changed of body weight more than 10% within 6 month before the first visit 5) Following diseases : - myocardial infarction, stroke - hypertension (Systolic Blood Pressure =140 mmHg OR Diastolic Blood Pressure =100 mmHg) - Diabetes (fasting glucose level = 180 mg/dL) - Liver dysfunction (AST, ALT = 2.5 X upper limit of normal range) - Renal dysfunction (serum creatinine = 1.4 mg/dL) - Chronic inflammatory bowel disease - Autoimmune disease, hyperthyroidism, hypothyroidism or malignant tumor 6) Women receiving hormone therapy 7) Chronic smoker (= 20 cigarettes / day) 8) Subjects with alcoholism or subjects who consume of alcohol more than 140g per week (example: soju about 2.5 bottles/week OR 2.5 glasses/day) 9) Excessive exercise (= 10 hours / week) 10) Participation in other human study within 4 weeks before the first visit 11) Subjects who are sensitive to Cynanchum wilfordii 12) Pregnant or lactating women 13) Any condition that the principal investigator believes may put the subjects at undue risk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood lipid profiles | — |
Secondary
| Measure | Time frame |
|---|---|
| Markers of inflammation and blood circulation ;Vital sign, adverse events;Clinical pathology examination, electrocardiography | — |
Countries
Korea, Republic of
Contacts
Public ContactYoung Hong
Seoul National University Hospital
Outcome results
None listed