None listed
Conditions
Interventions
Dietary Supplement : Subjects were randomly allocated at placebo group, experiment groups (Cortex Mori Radicis extract) for a week.
Treatment group: Cortex Mori Radicis extract, 400mg , twice a day,
Sponsors
Seoul National University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. over 18 years old, healthy person 2. Able to communicate (excluding those who are illiterate or unable to fully understand the survey questions) 3. Understand investigational study, cooperative (willing to postpone previously scheduled for elective surgery) and able to participate until the end of the study.
Exclusion criteria
Exclusion criteria: 1. Back Depression Inventory(BDI) = total score 24 2. Perceived Stress Scale-14(PSS-14) = total score 18 3. History of heart surgery and take medication that affect autonomic nervous system or heart function 4. Subject who has participated in another investigational study within 4 weeks prior to the first visit 5. body mass index >30kg/m2 or <18 kg/m2 6. having mental and physical problems or takes psychiatric drugs 7. Any condition that the principal investigator believes may put the subjects at undue risk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stress index of electroencephalography(EEG), Heart rate variability(HRV) and bio-signal | — |
Secondary
| Measure | Time frame |
|---|---|
| saliva test(cortisol, Dehydroepiandrosterone, DHEA);blood test(cortisol, cytokine);beck depression inventory, state trait-anxiety scale-state, perceived stress scale-14, stress response inventory, pittsburgh sleep quality index, fatigue severity scale, visual analogue scale;vital sign, body weight change, physical examination, blood test(complete blood count, liver function test, lipid etc.) | — |
Countries
Korea, Republic of
Contacts
Public ContactJINYOUNG KIM
Seoul National University
Outcome results
None listed