None listed
Conditions
Interventions
None listed
Sponsors
Korea Institute of Oriental Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Premenopausal women aged from 20 to 45 lived in Gwangju or Jeonnam province. 2. Android obese type: body mass index (BMI) = 25 kg/m2 and waist to hip ratio (WHR) = 0.90 3. Gynoid obese type: BMI = 25 kg/m2 and WHR <0.85 4. Subjects who clearly understood the purpose and specificity after the full explanation of the study, and signed an informed consent with voluntary participation.
Exclusion criteria
Exclusion criteria: 1. Patients with hypertension or subjects not diagnosed to hypertension but whose systolic blood pressure (SBP) is greater than 160 mmHg or diastolic blood pressure (DBP) is greater than 90 mmHg at the screening date. 2. Hyperlipidemia (LDL-cholesterol = 160 mg/dL or triglyceride = 500 mg/dL) 3. Diabetes or subjects whose fasting blood glucose level is greater than 126 mg/dL at the screening date. 4. Endocrine diseases such as hypothyroidism or Cushing syndrome, which can be affect to individual's weight. 5. Cardiovascular disease (heart failure, angina pectoris, myocardial infarction, and aherosclerotic heart disease) or with transplant of electric devices such as pacemaker. 6. Malignant neoplasm or lung diseases. 7. Severe renal disease (creatinine > 2.0 mg/dL) 8. Liver function disorder (alanine transaminase (ALT) or asparate aminotransferase (AST) is greater than 2.5 folds from the maximum of normal range) 9. Musculoskeletal complication or rheumatoid disease 10. Mental disorder: depression, anxiety neurosis, schizophrenia, eating disorder, alcoholism, continuous drug use. 11. Suspicious to use of drugs such as amphetamine, barbiturates, cocaine, opiods, cocaine, opioids, benzodiazepines and so on when subject has the history of drug abuse. 12. Pregnancy, nursing mother, or having the history of any contraceptives. 13. Irregular menstruation cycle generally or more than three months. 14. rapid weight variation for a month (more than 5 kg) 15. Participating any commercial diet program or antiobesity medication for the past three months. 16. Unable to perform single-stage sub-maximal treadmill walking test 17. Current smoker 18. Participate any clinical trials within three months 19. Sensitive reaction to the general pathological test 20. Refusal to an informed consent. 21. Principal investigator or research investigator deems subjects inappropriate to participate the clinical study. 22. Subjects under the absolute/relative contraindication of exercise test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulse pressure index (PPI) measured at Gwan location on the left-wrist radial artery | — |
Secondary
| Measure | Time frame |
|---|---|
| PPI measured at Chon and Cheok location on the left wrist radial artery;Pulse depth index (PDI) measured at Gwan, Chon, and Cheok location on the left wrist radial artery;Pulse volume index (PVI) measured at Gwan, Chon, and Cheok location on the left wrist radial artery;Change of hemodynamic measures: heart rate variablilty; area of averaged photoplethysmogram signals, respiration) at Gwan location on the radial artery before/after the single-stage sub-maximal test.;Change of radial artery pulse measures (PPI, PDI, PVI) at Gwan on the left radial artery before/after the single-stage sub-maximal treadmill walking test. ;Body composition analyzer measures: Visceral fat area (VFA), body fat mass (BFM), percent body fat (PBF), and fat free mass (FFM);Anthropometric measures (neck, chest, waist, brachia, thigh, and hip circumference);Total score of Korea version of quality of life questionnaire (KOQOL) | — |
Countries
Korea, Republic of
Contacts
Public ContactMoon-Jeong Kim
Wonkwang University, Korean Medical School, Gwangju Medical Center
Outcome results
None listed