Effect of early chemotherapy on angiogenesis after laparoscopic resection in colorectal cancer patients

Effect of early FOLFOX chemotherapy on angiogenesis after laparoscopic colorectal resection in colorectal cancer patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0001433

Enrollment

168

Registered

2015-04-02

Start date

2012-07-30

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Colorectal cancer patients treated with minimally invasive surgery followed by adjuvant FOLFOX chemotherapy were randomly assigned to two groups: the FOLFOX group, FOLFOX on postoperative day (

the control group, FOLFOX on POD 21. FOLFOX4 chemotherapy: Leucovorin 200 mg/m2 iv over 2 hrs before 5-FU, d1 and 2

5-FU 400 mg/m2 iv bolus and then 600 mg/m2 iv over 22 hrs, d 1 and d2

Oxaliplatin 85 mg/m2 iv d1 Blood sampling is performed preoperatively, and POD 3, POD 7-9, POD 9-11, POD 21.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria are aged 18-80, American Society of Anesthesiologists classification = 2, Clinical stage = 3, and laparoscopic or robotic surgery.

Exclusion criteria

Exclusion criteria: Exclusion criteria are preopeartive chemotherapy or radiotherapy, prior history of other cancer, major complications (Dindo classification =3), and not having postoperative FOLFOX4 chemotherapy

Design outcomes

Primary

Measure	Time frame
levels of plasma VEGF, Ang-1, Ang-2, TSP-1	—

Secondary

Measure	Time frame
Safety of early FOLFOX chemotherapy	—

Countries

Korea, Republic of

Contacts

Public ContactByung Eun Yoo

Korea University Anam Hospital

Outcome results