Effect of a 12-week cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0001385

Enrollment

Registered

2015-02-23

Start date

2014-05-29

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Behavioral, Others : The participant in home-based cognitive intervention group have to do homework for about 30minutes -6pages home study material and 1page a diary - 5days per week for 12 weeks. She

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. memory complaint corroborated by a participant and an informant 2. delayed recall score on the Seoul Verbal Learning Test (SVLT) at or below -1 standard deviations from the mean of the age and education-normative values among the Korean population 3. Global CDR(Clinical Dementia Rating) score is 0.5, Memory CDR(Clinical Dementia Rating) score is 0.5 or 1. 4. normal functional activities. S-IADL score :0-7 5. Not diagnosed with dementia 6. Modified Hachinski Ischemic Score (HIS): 0-4 7. He/She can read and write 8. 50 to 85 years of age 9. brain magnetic resonance imaging or CT showing no clinical evidence of other diseases (i.e., normal pressure hydrocephalus, brain tumor, cerebrovascular disease) capable of producing cognitive impairment. 10. written informed consent

Exclusion criteria

Exclusion criteria: 1. any patient who were involved in other clinical trials or treated with experimental drug within 4 weeks 2. any patients with any severe or unstable medical disease that may prevent the patient from completing all study requirements (i.e., unstable or severe asthma or cardiovascular disease, active gastric ulcer, severe hepatic or renal disease) 3. any patients with clinically significant laboratory abnormalities such as an abnormal thyroid function test, abnormal low level of vitamin B12 or folate, or positive venereal disease research laboratory test 4. ny patients with any primary neurodegenerative disorder or psychiatric disorder other than AD (i.e., Parkinson's disease, schizophrenia, or major depressive disorder) 5. any patiens with any history of drug or alcohol addiction during the past 10 years 6. any hearing or visual impairment that can disturb the efficient evaluation of the patient

Design outcomes

Primary

Measure	Time frame
Modified Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-cog)	—

Secondary

Measure	Time frame
Controlled Oral Word Association Test ;Color-Word Stroop test;Digit symbol test;Korean Mini-Mental State Examination (K-MMSE);Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB);Korean version of the Alzheimer disease 8 (K-AD8);Korean version of the Geriatric Depression Scale-short form (SGDS-K) ;Subjective cognitive assessment;Brain metabolic change with brain PET-CT(Positron emission tomography);Story recall test;Digit span forward & backward;Controlled Oral Word Association Test (Animal)	—

Measure

Time frame

Controlled Oral Word Association Test ;Color-Word Stroop test;Digit symbol test;Korean Mini-Mental State Examination (K-MMSE);Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB);Korean version of the Alzheimer disease 8 (K-AD8);Korean version of the Geriatric Depression Scale-short form (SGDS-K) ;Subjective cognitive assessment;Brain metabolic change with brain PET-CT(Positron emission tomography);Story recall test;Digit span forward & backward;Controlled Oral Word Association Test (Animal)

—

Countries

Korea, Republic of

Contacts

Public ContactJieun Park

Dong-A University Hospital

Outcome results