None listed
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Frequency of muscle cramps: more than once every 2 weeks irreguarding sites of cramps 2. Serum bilirubin: less than 5 mg/dL 3. Serum AST and ALT: less than 200 U/L, each 4. Serum creatinine: less than 2.0 mg/dL 5. INR: less than 2.0 6. Age is more than 18 years olds who voluntarily decide the participation of the study and sign the consent. 7. The patients who can be possible to follow up during the study periods. 8. The patients who accord with the wash-out criteria and agree to keep the restriction rule during the study
Exclusion criteria
Exclusion criteria: 1. The patients who accompany other disease evoking muscle crapms such as vessel occlusive disease, peripheral neuropathy, postphlebitic syndrome, thyroids disease. 2. Absolute granulocyte counts: less than 500/mm3 3. Platelet counts: less than 50,000/mm3 4. The patient who have no sign of aggrevation of HCC such as fever, deterioration of liver function, abdominal aortic aneurysm, venous thrombosis 5. The patients who is inappropriated this study confirmed by researchers 6. Women who have posive urine hCG.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The frequency and duration of muscle cramps | — |
Secondary
| Measure | Time frame |
|---|---|
| Child-Pugh score, Adverse events and overall safety | — |
Countries
Korea, Republic of
Contacts
Daegu Catholic Univercity Medical Center