None listed
Conditions
Interventions
Drug : randomized participants were prescribed to either Taeumjowee-tang, Yanggyuksanhwa-tang, Palmulgunja-tang to administer twice a day at each visit for total 4 weeks.
Sponsors
Dongguk University Ilsan Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) 15 typical constitution patients who were selected in 2013 clinical trials each groups(total 45 patients) 2) Among all men and women aged between 19 and 65 years 3) patients who do not correspond to the exclusion criteria
Exclusion criteria
Exclusion criteria: 1) patients with any condition that can affect weight gain such as hypothyroidism, cushing syndrome 2) heart disease(heart failure, angina pectoris, myocardial infarction) 3) cancer or lung disease 4) liver dysfunction(ALT(Alanine Aminotransferase), AST(Aspartate Aminotransferase) = 2.5 fold upper limit of normal) 5) patients who are diagnosed with cholelithiasis 6) severe renal dysfunction (Cr >2.0mg/dl) 7) Narrow angle glaucoma 8) neuropsychiatric diseases(schizophrenia, epilepsy, alcoholism, drug addiction, anorexia nervosa, hyperphagia) 9) past history of stroke, transient ischemic heart disease 10) eating disorder such as anorexia nervosa and bulimia nervosa 11) patients who have taken anorexiants, relievers(without prescription), oral steroid, thyroid hormone, amphetamine, cyproheptadine, phenothiazine, or any other medication within 3 months that can affect absorption, metabolism, excretion which can affect on weight. 12) who are on narcotics and neuropsychological drugs for weight reduction 13) other forbidden treatments(insulin, hypogycemic agents, antidepressants, anti serotonin reuptake inhibitor, sodium pentobarbital, antipsychotics, drugs concerned with misuse) 14) patients who underwent anatomical change such as incision which makes it difficult to conduct physical measurements 15) patients who underwent surgeries for weight reduction(gastroplastia) 16) pregnant women, breast feeder, women planning a pregnancy and those who do not agree to use adequate contraception such as oral contraceptives, hormone transplant, IUD, spermicide, condom, celibacy. 17) patients who have taken other medications provided by clinical trial within a month 18) patients who have lost more than 10% of body weight within 6 months 19) patients who are judged to be unacceptable for candidate by person in charge of clinical trial 20) patients who have given up on smoking within past 3 months but who have irregular smoking habit 21) patients who had received antiboitics or probiotics within 1 month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| difference of intestinal microbiota ratio according to Sasang typology and herbal medicine group ;changes in metabolite pattern was analyzed by LC-MS | — |
Secondary
| Measure | Time frame |
|---|---|
| weight, body composition (body fat mass, muscle mass), waist circumference, blood pressure, BMI;drug reaction according to Sasang typology and herbal medicine group ;blood lipid profile (triglyceride, total cholesterol, HDL cholesterol), blood glucose, amylase, lipase | — |
Countries
Korea, Republic of
Contacts
Public ContactHojun Kim
Dongguk University Ilsan Hospital
Outcome results
None listed