Effects of serotonin antagonists administered before spinal anesthesia on spinal induced hypotension and postoperative nausea and vomiting: comparison of ramosetron and ondansetron

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0001216

Enrollment

117

Registered

2014-08-29

Start date

2014-07-16

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Patients were randomized to receive either ramosetron 0.3 mg, ondansetron 4 mg or ondansetron 8 mg intravenously. Each drug was infused 5 minutes before performing spinal anesthesia.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients undergoing spinal anesthesia

Exclusion criteria

Exclusion criteria: Hypersensitivity on 5-HT3 receptor antagonist uncontrolled hypertension intake of selective serotonin reuptake inhibitor

Design outcomes

Primary

Measure	Time frame
The gap between baseline mean arterial pressure and lowest mean arterial pressure measured during 30 min after spinal anesthesia	—

Secondary

Measure	Time frame
The gap between baseline systolic arterial pressure and lowest systolic arterial pressure measured during 30 min after spinal anesthesia;The gap between baseline diastolic arterial pressure and lowest diastolic arterial pressure measured during 30 min after spinal anesthesia;incidence of postoperative nausea and vomiting	—

Countries

Korea, Republic of

Contacts

Public ContactHyun-Jung Shin

Seoul National University Bundang Hospital

medidoc@nate.com

Outcome results