Plasma metabolomics and proteomics profiling in subjects with low-grade inflammation given a dietary lipid challenge

Plasma metabolomics and proteomics profiling in subjects with low-grade inflammation given a dietary lipid challenge: A case of modulation with a traditional herb (Angelica keiskei)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0001145

Enrollment

Registered

2014-06-27

Start date

2014-04-23

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Dietary Supplement : -Arm A : Consumption of high fat liquid formula with placebo at week 0. Consumption of high fat liquid formula with Angelica keiskei(low dose)at week 1. Consumption of high fat li

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Subject who voluntarily agrees to participate and sign in informed consent form 2) Subject who can participate all visits after rondomization 3) Age: 20 years = Age = 65 years 4) BMI (Body Mass Index): = 25 kg/m2 5) CRP (C-reactive protein): 1.0 - 8.1 mg/L

Exclusion criteria

Exclusion criteria: 1) Continuous consumption of dietary supplement or oriental medicine or drug that affect inflammation, antioxidative capacity and lipid metabolism within 4 weeks before the first visit 2)Current consumption of anticoagulant within 4 weeks before the first visit 3)Following diseases : Chronic inflammatory disease, diabetes, liver dysfunction, renal dysfunction, cardiovascular diseases (hypertension, stroke, etc.), thyroid diseases, etc. 4)Decrease of more than 4 kg body weight within 4 weeks before the first visit (weight-loss therapy) 5)Excessive exercise (= 7 hours / week) 6)Smoking = 10 cigarettes / day 7)Alcohol consumption 140g / week 8) Subjects with hypersensitivity to test materials 9) Participation in other human study within 4 weeks before the first visit 10) Pregnant or lactating women 11) Any condition that the principal investigator believes may put the subjects at undue risk

Design outcomes

Primary

Measure	Time frame
Markers of Inflammation	—

Secondary

Measure	Time frame
Antioxidative markers;Markers of blood glucose ;Blood lipid profiles	—

Countries

Korea, Republic of

Contacts

Public ContactSoo-yeon Park

Ewha Womans University

lub486lub@naver.com+82-2-3277-3087

Outcome results