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The comparative study to evaluate the effect of palonosetron monotherapy versus palonosetron with midazolam combination therapy for prevention of postoperative nausea and vomiting in breast cancer surgery

The comparative study to evaluate the effect of palonosetron monotherapy versus palonosetron with midazolam combination therapy for prevention of postoperative nausea and vomiting in breast cancer surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CRIS
Registry ID
KCT0001114
Enrollment
104
Registered
2014-05-23
Start date
2013-12-12
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : There were randomly allocated to group P and group P-M. After intubation, 0.075mg of palonosetron was injected in both groups. Patients in group P were administered patient controlled analgesia

Sponsors

Pusan National University Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: female patients with American Society of Anesthesiologists physical status 1-2, who were aged 18-60 years, and were scheduled to undergo general anesthesia and postoperative intravenous patient controlled analgesia for breast cancer surgery

Exclusion criteria

Exclusion criteria: psychiatric disease chronic pain history of preoperative analgesics contraindication of fentanyl or midazolam when the PCA cannot be applied to patients

Design outcomes

Primary

MeasureTime frame
complete response( no nause and no vomiting remaining patient controlled analgesia)—

Secondary

MeasureTime frame
sedaton, sleep—

Countries

Korea, Republic of

Contacts

Public ContactJeong Min Hong

Pusan National University Hospital

ccarrot@pusan.ac.kr+82-51-240-7399

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026