High-dose vs. low dose proton pump inhibitor infusion for the prevention of ulcer bleeding after endoscopic submucosal dissection

High-dose vs. low dose Proton Pump Inhibitor infusion for the prevention of ulcer bleeding after Endoscopic Submucosal Dissection

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0001089

Enrollment

300

Registered

2014-04-22

Start date

2012-01-10

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : For the bolus group, pantoprazole 40mg IV bolus was administered every 12 hours for 72 hours. For the continuos infusion group, pantoprazole was continuously infused at 8mg/hr for 72 hours.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: From March 2012 to February 2013, patients who gave written informed consent were enrolled. The indications for endoscopic submucosal dissection were early gastric cancer, gastric adenomas or gastric submucosal layer tumors which were confirmed by endoscopic ultrasound.

Exclusion criteria

Exclusion criteria: The exclusion criteria were: age below 20 or above 80; previous gastroesophageal surgery; or history of allergy to any proton pump inhibitor.

Design outcomes

Primary

Measure	Time frame
Delayed bleeding after endoscopic submucosal dissection	—

Secondary

Measure	Time frame
The incidences and risk factors of high risk ulcer stigma	—

Countries

Korea, Republic of

Contacts

Public ContactCHEOLWOONG CHOI

Pusan National University Yangsan Hospital

Outcome results