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Impact of vancomycin pharmacokinetic properties on treatment outcome in Staphylococcus aureus infection

Clinical significance of vancomycin AUC (area under the concentration) over MIC (minimal inhibitory concentration) in methicillin-resistant Staphylococcus aureus bacteremia

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0001082
Enrollment
230
Registered
2014-04-21
Start date
2014-01-08
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Seoul National University Bundang Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Among all adult (>=18years) patients with Staphylococcus aureus bacteremia at participating hospital during the study period 1) Patients who agree to the gathering clinical information about S. aureus bacteremia by means of an informed consent. 2) Patients who fulfill the criteria of a waiver: Patients who died or transferred within 2 weeks after the onset of bacteremia, an informed consent was waived by institutional review board. Vancomycin-treated patient with methicillin-resistant Staphylococcus aureus bacteremia who fulfill the above criteria.

Exclusion criteria

Exclusion criteria: Patienst who do not agree the participation in this study, except for patients who fulfill the criteria of a waiver of informed consent.

Design outcomes

Primary

MeasureTime frame
Treatment failure: (1) death within 30 days, or (2) persisent MSSA bacteremia for more than 7 days, or (3) recurrence of MSSA bacteremia within 30 days after completion of antibiotic treatment) ;MRSA bacteremia-associated mortality

Secondary

MeasureTime frame
Analysis of risk factors for treatment failure ;Replacement of antibiotics due to adverse effect of vancomycin;Analysis of relationship between vancomycin MIC and treatment outcome;Analysis of relationship between archievement of target trough level and treatment outcome

Countries

Korea, Republic of

Contacts

Public ContactKyoung-Ho Song

Seoul National University Bundang Hospital

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026