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A comparison of clinical outcomes between cefazolin and nafcillin therapy for methicillin-susceptible Staphylococcus aureus bacteremia

A comparison of clinical outcomes between cefazolin and nafcillin therapy for methicillin-susceptible Staphylococcus aureus bacteremia

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0001081
Enrollment
400
Registered
2014-04-21
Start date
2014-01-08
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Seoul National University Bundang Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Among all adult (>=18years) patient with MSSA bacteremia at participating hospitals was ascertained during the study period 1) Patient who received cefazolin or nafcillin as definite antibiotics 2) Patient who agree the gathering clinical information about S. aureus bacteremia by inform consent. 3) Patient who fulfill the criteria of waiver of informed consent: Patient who died or transferred within 2 weeks after the onset of bacteremia was waived by institutional review board.

Exclusion criteria

Exclusion criteria: Patient who do not agree the participation in this study, except for patient who fulfill the criteria of waiver of informed consent.

Design outcomes

Primary

MeasureTime frame
Treatment failure: [(1) switching antibiotics due to clinical failure; (2) premature discontinuation of antibiotics due to drug adverse effect, (3) recurrence of MSSA bacteremia, or (4) MSSA bacteremia associated mortality];3 months mortality

Secondary

MeasureTime frame
Persistent bacteremia;7day mortality;Analysis of clinical implication of cefazolin inoculum effect

Countries

Korea, Republic of

Contacts

Public ContactShinwon Lee

Pusan National University Hospital

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026