None listed
Conditions
Interventions
Drug : ramosetron 0.3, 0.45, 0.6mg bolus intravenous injection just before surgery accoring to the group.
Sponsors
Chonnam National University Hospital Hwasun Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: .American Society of Anesthesiology Physical status classification is 1 or 2 patients. .19 years of age or over .Surgery under elective general anesthesia. .Patients signed up the voluntary written consent to participate in clinical studies. .Apfel's Postoperative nausea and vomiting risk score is 3 or more.
Exclusion criteria
Exclusion criteria: .Under nineteen years of age .Patients with known hypersensitivity for fentanyl, ketorolac or test drug(Ramosetron). .Medications within 24 hours before surgery have potentials affecting the postoperative nausea and vomiting such as antiemetics, steroids, antihistamines,or psychotropic drugs. .American Society of Anesthesiology Physical status classification is 3 or more patients. .Patients go through nasogastric tube after surgery, .Hemoglobin is less than 10.0g/dL. .Patients participated in a screening of another clinical trial of medication within 30days. .Patients donate more than 450ml blood or blood products within 30days. .Patients with active hepatitis .Heavy aldohol drinker or clinical significant findings in patients with alcoholism .Patients with organ dysfunction or history associated with alcohol. .Besides the above all, investigators have determined that the patient is not appropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Non-compartment pharmacokinetic analysis ;Populational pharmacokinetic analysis with NONMEM ? level 2;Populational pharmadynamic analysis with NONMEM ? level 2 | — |
Secondary
| Measure | Time frame |
|---|---|
| collection and reporting of all adverse events | — |
Countries
Korea, Republic of
Contacts
Public ContactSeongwook Jeong
Chonnam National University Hospital Hwasun Hospital
Outcome results
None listed