None listed
Conditions
Interventions
Dietary Supplement : Oral administration of CJ_AJ (Citrus junos Siebold ex Tanaka extract 500 mg/day) or placebo, once daily for eight weeks
Sponsors
Ajou University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1) Male adult smokers more than 10 cigarettes per day 2) Platelet eggregation results > 70% at screening 3) Wiling to provide own written informed consent to trial participation
Exclusion criteria
Exclusion criteria: 1) Intake of any prescription drug for myocardial infarction, angina or bleeding disorders 2) Intake of aspirin, anti-coagulants or anti-platelet agents within 2 weeks prior to screening 3) Intake of red ginseng, ginseng, fermented bean paste within 2 weeks prior to screening 4) Uncontrolled hypertension (systolic blood pressure > 160 mmHg or diastolic blood pressure > 100 mmHg) 5) Uncontrolled diabetes mellitus (fasting glucose > 180mg/dl, or intake of hypoglycemic agents within 3 months prior to screening) 6) Uncontrolled thyroid diseases 7) Surgery under general anesthesia within 3 months prior to screening 8) Serum creatinine > 2 x upper normal limit 9) Serum alanine Transaminase, aspartate Transaminase > 3 x upper normal limit 10) Subject with severe epigastric soreness or indigestion 11) Participation of other clinical study within 3 months prior to screening 12) Ineligible for study participation due to other reasons, according to the investigator’s judgment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Platelet aggregation test | — |
Secondary
| Measure | Time frame |
|---|---|
| Serotonin;Thromboxane B2;C-reactive protein;Coagulation tests;Lipid panel | — |
Countries
Korea, Republic of
Contacts
Public ContactDOO-YEOUN CHO
Ajou University Hospital
Outcome results
None listed