None listed
Conditions
Interventions
None listed
Sponsors
Hanyang University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria -20 years to 70 years -clinically diagnosed for nonalcoholic liver disease -diagnosed for fatty liver by ultrasonography or CT -serum ALT or AST is greater than 40 IU/L
Exclusion criteria
Exclusion criteria: Exclusion criteria -alcohol intake (> 140g/week in man, >70g/week in woman) -diabetes requiring insulin therapy -immuno-suppressive therapy (ex. steroid) -serum creatinine of 5.0 mg/dL or greater -hepatitis B as defined by presence of hepatitis B surface antigen -hepatitis C as defined by presence of HCV-RNA or positive hepatitis C antibody -any suspicion of other liver disease such as autoimmune hepatitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| comparison of LXR expression between NASH, NAFLD and control group | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. clinical characteristics as expression level of LXR;2. correlation of NPC1L1, ABCG5/8, ABCA1, SREBP-1C expression;3. compare the previous studies with animals and this study with human liver samples | — |
Countries
Korea, Republic of
Contacts
Public ContactDAE WON JUN
Hanyang University Seoul Hospital
Outcome results
None listed