Clinical trial of human neural stem cell transplantation in patients with traumatic spinal cord injury

Clinical trial of allogenic human fetal brain-derived neural stem/progenitor cell transplantation in patients with traumatic spinal cord injury

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0000879

Enrollment

Registered

2013-10-11

Start date

2006-06-01

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Biological/Vaccine, Stem Cell, Procedure/Surgery : 1) Human neural stem cells within cell growth factor containing medium will be triturated into single cells by trypsin treatment and then washed with

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ? Adults over 19th years below 70th years ? Patients with traumatic spinal cord injury ? Patients with complete sensory and motor nerve function injury (ASIA-A), when measured by ASIA2002 standard ? Patients with complete motor and incomplete sensory nerve function injury (ASIA-B),when measured by ASIA2002 standard ? Patients within 6 month(subacute) or 2 years(chronic) after spinal cord injury

Exclusion criteria

Exclusion criteria: ? Patients who received cell therapy before ? Patients with concomitant skeletal fractures or other assciated injuries which could affect neurological examination ? Patients with severe other systemic disease which could affect neurological examination ? Patients with tumorous spinal cord injury or disease ? Patients with concomitant joint and muscular atrophy ? Patients with concomitant progressive or non-progressive other neurological illness ? patients with substance abuse or other psychiatric disorders ? Patients who are unfit for cell transplantation judged by the physician in charge ? Patients with concurrent mechanical spinal cord compression which required secondary decompression operation ? Patients with multiple spinal cord injury ? Patients with other injuries or diseases which could cause side effects during surgery under general anesthesia ? Patients who participated in another clinical trial within the past month

Design outcomes

Primary

Measure	Time frame
Neurological examination	—

Secondary

Measure	Time frame
ASIA2002 scoring;Spinal MRI	—

Countries

Korea, Republic of

Contacts

Public ContactKook In Park

Yonsei University Health System, Severance Hospital

kipark@yuhs.ac+82-2-2228-2059

Outcome results