NSAID(Non-Steroidal Anti-Inflammatory Drugs) Discontinuation study on Disease stable Rheumatoid arthritis patients

Non-steroidal anti-inflammatory drug Discontinuation study on Disease stable Rheumatoid arthritis patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0000870

Enrollment

110

Registered

2013-10-01

Start date

2013-07-30

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Patients will stop taking NSAID(Non-Steroidal Anti-Inflammatory Drugs) agents (including patch form) after enrollment and be followed up for 16 weeks. If joint pain develops, patients will be a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients with RA who fulfill the 1987 ACR classification criteria for RA and diagnosed at least 6 months before enrollment. 2) DAS28-ESR < 3.2 in two consecutive examinations apart for at least 1 month 3) Regularly taking any type of NSAID for more than 4 weeks (irrespective of dose) 4)Patient who take regularly takes less than 7.5mg of oral steroids over a month. 5)Patients who understand about the study, and provided informed consent

Exclusion criteria

Exclusion criteria: 1) Patients enrolled in other phase 1,2,3 clinical trials. 2) Patients who had any type of adverse effects of acetaminophen (Patients who has elevated AST/ALT levels more than 2 times of upper normal range of reference value) 3) Patients with concurrent fibromyalgia or severe osteoarthritis with Kellgren grade III/IV

Design outcomes

Primary

Measure	Time frame
Proportion of patients who do not take any type of NSAID(Non-Steroidal Anti-Inflammatory Drugs) during the 16 weeks of study period	—

Secondary

Measure	Time frame
Change of DAS-28 score during study period ;Change of RAPID3(Routine Assesment of Patient Index Data) score during study period;Clinical characteristics of patients who re-start any type of NSAID(Non-Steroidal Anti-Inflammatory Drugs) during study period;Clinical characteristics of patients who do not take any type of NSAID(Non-Steroidal Anti-Inflammatory Drugs) during study period	—

Countries

Korea, Republic of

Contacts

Public ContactKichul Shin

Seoul Metropolitan Government Seoul National University Boramae Medical Center

Outcome results