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Association of genetic variants in GABA-A Receptor a1 and Sensitivity of Midazolam

Association between GABA-A Receptor a1/a3 s ubunit polymorphism and sleep induction time of midazolam

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0000848
Enrollment
100
Registered
2013-09-16
Start date
2011-08-01
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Korea University Anam Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: patients aged 20-40 years old with ASA 1 or 2 undergoing elective surgery

Exclusion criteria

Exclusion criteria: (1) patients below 20 or above 40 years old (2) opioid or other drug that effect on the benzodiazepine within 1 week(3) alcohol or other drug abuse, pscychiatric or neurologic disease (4) abnormal recation with benzodiazepine (5) refuse this study.

Design outcomes

Primary

MeasureTime frame
GABA-A receptor genetic polymorphism—

Secondary

MeasureTime frame
Total dose of midazolam;Lowest bispectral index(BIS) value during induction time;Time to obtain bispectral index(BIS) 70—

Countries

Korea, Republic of

Contacts

Public ContactYoon Ji Choi

Inje University Seoul Paik Hospital

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026