Efficacy and safety of acclerated repetitive transcranial magnetic stimulation for patients with major depressive disorder

The efficacy and safety of accelerated repetitive transcranial magnetic stimulation (rTMS) compared with conventional rTMS in major depressive disorder: active treatment controlled, randomized, non-inferiority study

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0000666

Enrollment

Registered

2013-02-08

Start date

2012-08-23

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Procedure/Surgery : Active treament group : accelerated rTMS (left prefrontal cortex, 10Hz, 110% of motor threshold), 5 sessions per day for 3 days Comparison group : conventional rTMS (left prefront

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Patients taking two or less antidepressant medications without change of dosage within two weeks - Illness duation is less than 5 years - Montgomery-Asberg Depression Rating Scale score is equal to or higher than 22

Exclusion criteria

Exclusion criteria: - Patient who has other Axis I disoder including schizophrenia, bipolar disorder and so on. - Patient who has been treated with rTMS or electroconvulsive therapy. - Past history of seizure disorder - 1st degree family history of seizure disorder - Substance dependence or other medical illnesses which have significant effect on brain function - Organic brain disease such as brain tumor or intracranial hemorrhage - Patients who have taken medication lowering seizure threshold (ex: theophylline) - Patients who have artificial metal in the body (cochlear implantation or pacemaker) - Clinically inappropriate patient for rTMS

Design outcomes

Primary

Measure	Time frame
Hamilton Depression Rating Scale	—

Secondary

Measure	Time frame
Frequency, Intensity, Burden of Side Effect Rating scale	—

Countries

Korea, Republic of

Contacts

Public ContactJeong-Ho Seok

Yonsei University Health System, Gangnam Severance Hospital

Outcome results