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A prospective, single-center, randomized study to evaluate the effect of sarpogrelate, a selective serotonin receptor antagonist, and high dose statin on the reduction of coronary spasm in the patients with variant angina

A prospective, single-center, randomized study to evaluate the effect of sarpogrelate, a selective serotonin receptor antagonist, and high dose statin on the reduction of coronary spasm in the patients with variant angina

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
CRIS
Registry ID
KCT0000623
Enrollment
200
Registered
2013-01-02
Start date
2012-11-08
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : group A: sarpogrelate 100 mg bid + atorvastatin 80 mg qd, group B: sarpogrelate 100 mg bid + no statin or simvastatin 20 mg if LDL > 130 mg/dl, group C: placebo + atorvastatin 80 mg qd, grou

Sponsors

Samsung Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Age 20 ~ 70 years old 2) Clinical history of chest pain compatible with variant angina; morning chest pain aggravated by cold exposure. 3) Angiographically proven coronary spasm; TIMI flow < 3 by spontaneous coronary spasm or intracoronary ergonovine spasm provocation test.

Exclusion criteria

Exclusion criteria: 1) Cardiac arrest by coronary spasm 2) Left main coronary spasm 3) Significant fixed coronary artery stenosis; Diameter stenosis > 70% in the major epicardial artery by coronary angiography 4) LV ejection fraction 2.0) 6) Significant liver disease (AST or ALT > 100 U/ml) 7) Renal failure (S-Cr > 2.0 mg/dl) 8) hypersensitivity for statin 9) Pregnancy

Design outcomes

Primary

MeasureTime frame
Ergonovine provocation test—

Secondary

MeasureTime frame
C-reactive protein level—

Countries

Korea, Republic of

Contacts

Public ContactKye-eun Chang

Samsung Medical Center

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026