Dexmedetomidine dosage for optimal level of sedation in elderly patients under spinal anesthesia

Dexmedetomidine ED50 for optimal level of sedation in elderly patients under spinal/spinal-epidural anesthesia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0000599

Enrollment

Registered

2012-12-06

Start date

2012-12-13

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Others : According to randomly assigned group, different loading dose of dexmedetomidine(Precedex®) is administered. In groups I, II, III, IV, V, dexmedetomidine 0.1, 0.3, 0.5, 0.7 or 1.0 mcg/kg is i

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Elderly patients (65yrs or older than 65 yrs) - ASA(American society of Anesthesiologists) physical status class I or II - under Spinal or combined spinal-epidural anesthesia for orpthopedic surgery or urologic surgery

Exclusion criteria

Exclusion criteria: -Patients with bradycardia (preanesthesia: HR <60 bpm) -Patients with hepatic disease or renal disease -Patients with neurologic disorder -Patients on sedatives or hypnotics -Sedatives or hypnotics before anesthesia -Other sedatives or hypnotics during surgery -Incooperative patients -Contraindication of spinal anesthesia such as coagulation abnormality -Spinal anesthetic level higher than T4 with persistent hypotension(systolic BP < 90 mmHg) in spite of ephedrine bolus (5-10 mg)

Design outcomes

Primary

Measure	Time frame
Sedation level (Ramsay sedation scale score)	—

Secondary

Measure	Time frame
vital signs;respiratory rate	—

Countries

Korea, Republic of

Contacts

Public ContactKye-Min Kim

Inje University Sanggye Paik Hospital

Outcome results