None listed
Conditions
Interventions
None listed
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Crohn' disease: patients who met at least 2 of the following criteria a) clinical history of abdominal pain, weight loss, malaise, diarrhea, and/or rectal bleeding; b) endoscopic findings of mucosal cobblestoning, linear ulceration, skip areas, or perianal disease; c) radiologic findings of stricture, mucosal cobblestoning, or ulceration; d) macroscopic appearance of bowel wall induration, mesenteric lymphadenopathy, and “creeping fat” at laparotomy; and e) pathologic findings of transmural inflammation and/or epithelioid granulomas. Only patients who met these criteria for at least 2 months are included. - Ulcerative colitis: patients who met all 3 of the following criteria a) a typical history of diarrhea or blood and pus or both in the stool for longer than 4 weeks; b) a typical sigmoidoscopic or colonoscopic picture with diffusely granular, friable, or ulcerated mucosa without rectal sparing or skip lesions or radiological signs of characteristic continuous granular or ulcerated mucosa; and c) characteristic histopathological signs of inflammation on biopsy. - Controls: subjects who do not have any evidence of inflammatory bowel disease and who gave an informed consent for being enrolled in this study
Exclusion criteria
Exclusion criteria: - IBD unclassified - Younger than 15 years - Not Korean ethnicity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical features and prognosis of Korean patients with inflammatory bowel disease;Serologic biomarker: ASCA, pANCA, Anti-I2, Anti-OmpC, Anti-CBir1;Genome wide association study and analysis;Illumina exome array | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical and genetic prognostic markers | — |
Countries
Korea, Republic of
Contacts
Public ContactByong Duk Ye
Asan Medical Center
Outcome results
None listed