Efficacy of proton pump inhibitor for chronic cough caused by gastroesophageal reflux; double-blind, placebo-controlled, randomized clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0000543

Enrollment

132

Registered

2012-09-24

Start date

2012-02-28

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Chronic chough patients are enrolled. They undergo 24-hour ambulatory esophageal pH monitoring and esophageal impedance test. After testing, they are randomely assigned as high dose PPI treatme

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: chronic cough patient from 18 to 70 years

Exclusion criteria

Exclusion criteria: ? less than 18 yrs, more than 70 yrs ? current smoker, ex-smoker within 3 months ? underlying lung disease ? Bronchial asthma patients ? postnasal drip patients ? Previously PPI failure patients ? Previously reflux surgery performed patients ? gastrointestinal malignancy or Barrett's esophagus ? Upper airway infection history within 8 weeks ? Currently taking PPI, H2-receptor antagonist, beta-blocker, ARB, steroid, anti-cholinergics

Design outcomes

Primary

Measure	Time frame
Cough VAS questionnaire;Cough LCQ questionnaire;Cough GSAS questionnaire	—

Countries

Korea, Republic of

Contacts

Public ContactJie-Hyun Kim

Yonsei University Health System, Gangnam Severance Hospital

Outcome results