Drug interaction of inhalation anesthetics and antiemetics.

QT interval-prolonging effects of sevoflurane and ondansetron in children : implication of drug interaction

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0000534

Enrollment

Registered

2012-09-12

Start date

2012-08-09

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : We compared QTc before and after drug administration. Sevoflurane concentration is regulated based on based on vital signs, as usual. ondansetrone 0.1mg/kg is administered before the administra

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: pediatric patient with the age of 3-12, undergoing scheduled surgery under general anesthesia.

Exclusion criteria

Exclusion criteria: hypersensitivity reaction with opioids or NSAIDS. patients who are in need of total intravenous anesthesia because of the risk of malignant hyperthermia of EP monitoring during surgery electrolyte imbalance or hypothyroidism. abnormal preoperative ECG finding. patients who are taking the drugs that affect the QT interval (ex. TCA, beta blocker, calcium channel blocker, antiarythmic agents).

Design outcomes

Primary

Measure	Time frame
change of the corrected QT interval (QTc) before and after the administration of ondansetron	—

Secondary

Measure	Time frame
change of the corrected QT interval (QTc) before and after the sevoflurane inhalation	—

Countries

Korea, Republic of

Contacts

Public ContactJi-Hyun LEE

Seoul National University Hospital

Outcome results