None listed
Conditions
Interventions
Procedure/Surgery : 36 patients with recalcitrant AD whose clinical conditions had not been effectively controlled by current standard medical therapies (topical moisturizers, topical corticosteroids,
Sponsors
Ajou University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 36 patients with recalcitrant AD whose clinical conditions had not been effectively controlled by current standard medical therapies (topical moisturizers, topical corticosteroids, topical calcineurin inhibitors, and oral antihistamines) for more than 6 months who visited out-patient clinic of the university hospital will be recruited. Written informed consent on this study will be received from all the participating patients and the patients will be divided into 2 experimental groups (12 patients in autologous plasma injection group, 12 patients in high molecular plasma protein injection group) and 1 control group (12 patients in saline injection group) for this study.
Exclusion criteria
Exclusion criteria: 1) Patients under the age of 16 2) Patients who are unable to agree on their own (emergency patients, patients with mental disability, patients with limited capacity to consent due to stroke or delirium caused by diabetes) 3) Pregnancy or planned pregnancy within 1 year 4) Skin condition not appropriate for blood sampling and transfusion 5) Patients with contraindication for blood transfusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Standardized clinical severity scoring system for atopic dermatitis (SCORAD) values measured before and after the treatment at 4 week intervals | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood test indicators(Serum concentrations of eosinophil cationic protein (ECP), albumin, and cytokine) | — |
Countries
Korea, Republic of
Contacts
Public ContactMyoung Kim
Ajou University Hospital
Outcome results
None listed