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1) To determine the prevalence of diaphragmatic dysfunction diagnosed by M-mode ultrasonography in medical intensive care unit patients and to assess the influemce of diaphragmatic dysfunction on weaning outcome 2) To elvaluate the theophylline effect on diaphragmatic dysfunction

Usefulness of ultrasonographic evaluation of diaphragmatic function in patients on weaning from mechanical ventilation

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0000377
Enrollment
90
Registered
2012-03-08
Start date
2010-05-10
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Asan Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Study subjects included the ICU patients who required mechanical ventilation for > 72 hrs and included when they met all of criteria for spontaneous breathing trial (discontinued neuromuscular blocker, RASS score +1~-2) and showed ultrasonographic diaphragm movement was < 1 cm depending on respiration.

Exclusion criteria

Exclusion criteria: Patients were excluded if they had a history of diaphragmatic palsy, cervical spine injury, or neuromuscular disease, a current thoracostomy; pneumothorax or pneumomediastinum, history of theophylline medication, uncontrolled arrhythmia or seizure, thyrotoxicosis, peptic ulcer

Design outcomes

Primary

MeasureTime frame
prevalence of ultrasonographic diaphragmatic dysfunction—

Secondary

MeasureTime frame
weaning time;total ventilation time;weaning sucess—

Countries

Korea, Republic of

Contacts

Public ContactJW Huh

Asan Medical Center

jwhuh@amc.seoul.kr+82-2-3010-3985

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026