None listed
Conditions
Interventions
None listed
Sponsors
Inha University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Alzheimer's disease 1) Dementia by DSM-IV 2) Probable AD by NINCDS-ADRDA 3) Slowly progressive cognitive decline, at least for 6 months 2. Subcortical Vascular Dementia (SVD) 1) vascular dementia as described by the DSM-IV 2) has at least one focal neurologic sign 3) severe ischemic changes on brain MRI 3. MCI 1) No dementia or normal 2) Memory complaint by subject or study partner 3) Objective cognitive impairment 4) Preserved Activies Daily Living 4. vascular MCI 1) Compatible with the criteria of MCI 2) has at least one focal neurologic sign 3) severe ischemic changes on brain MRI 5.SMI 1) Subjective memory impairment 2) No objective memory impairment 3) Preserved Activies Daily Living 6. FTLD FTLD by the Research criteria for frontotemporal dementia (Knopman et al. 2008) 1) Absence or insignificance of an anterograde amnesia and visuospatial impairment in the at least first 2 years of symptoms 2)Imaging demonstrating focal cerebral atrophy at least one of the following : the anterior temporal lobes, frontal lobes and insula or caudate nuclei
Exclusion criteria
Exclusion criteria: 1) Blindness or hearing loss to be unable to be tested 2)sick-sinus syndrome, a second or third degree atrioventricular block 3)severe pulmonary disease (acute, severe, or unstable asthma, severe COPD) 4)an active gastric ulcer 5)uncontrolled diabetes mellitus 6)severe hepatic, or renal disease 7)uncured malignancy 8)major depressive disorder, psychosis 9)mental retardation 10)a history of encephalitis 11)head trauma with loss of consciousness longer than one hour 12)a brain tumor, a traumatic intracranial hemorrhage or a subarachnoid hemorrhage 13) abnormal TFT 14) a deficiency in vitamin B12 or folate 15) neurosyphilis 16)metabolic encephalopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression of cognitive impairment | — |
Secondary
| Measure | Time frame |
|---|---|
| conversion to dementia in MCI , conversion to MCI or dementia in SMI | — |
Countries
Korea, Republic of
Contacts
Public ContactHye
Inha University Hospital
Outcome results
None listed