ramosetron vs. ramosetron plus dexamethasone after laparoscopic cholecystectomy

The comparison of ramosetron with ramosetron plus dexamethasone for postoperative nausea and vomitting after laparoscopic cholecystectomy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0000267

Enrollment

Registered

2011-11-14

Start date

2011-10-10

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Patietns are allocated randomly into two groups. Patients in ramosetron group was administered 1.6 ml of normal saline after induction of anesthesia and 0.3 mg ramosetron at the end of surgery.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) patients undergoing laparoscopic cholecystectomy, aged 19-65 2) ASA class I, II 3) informed consent

Exclusion criteria

Exclusion criteria: 1)gastrointestinal disease (gastritis, gastric cancer) 2)pregnancy, antidepressant medication 3)chemotherapy, chronic opioid user 4)antiemetic medication within 24hr before surgery 5)allergic to study medication 6)cardiovascular, respiratory, cerebrovascular,and hapatobiliary disease 7)obesity (more than 50% greater than their ideal body weight) 8) severe diabetes mellitus (serum HbA1c > 8%) 9)use of steroids or antiemetics within 1 month of surgery

Design outcomes

Primary

Measure	Time frame
vomitting;nausea,;retching,	—

Secondary

Measure	Time frame
rescue antiemetic;postoperative pain score ;rescue analgesic;headache;dizziness; stomach pain;sleeplessness;increased appetite;wound infection	—

Countries

Korea, Republic of

Contacts

Public ContactJungHee Ryu

Seoul National University Bundang Hospital

Outcome results