Effects of vasoconstrictors during liver transplantation

Perioperative effects of phenylephrine infusion during living donor liver transplantation on hemodynamics, acid-base balance, and global tissue oxygenation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0000264

Enrollment

Registered

2011-11-11

Start date

2007-06-19

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Patients undergoing living donor liver transplantation are randomly allocated into the control or phenylephrine groups. Patients in the control group receive conventionally accepted inotropic a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: liver transplant recipients with a systemic vascular resistance index < 1700 dyne·s·cm-5·m-2, pulmonary vascular resistance index < 150 dyne·s·cm-5·m-2

Exclusion criteria

Exclusion criteria: history of angina or myocardial infarction evidence of cardiac decompensation severe hemodynamic instability preoperative vasopressor administration primary renal dysfunction or hepatorenal syndrome retransplantation

Design outcomes

Primary

Measure	Time frame
amount of intraoperative bleeding	—

Secondary

Measure	Time frame
hemodynamic variables;variables for global tissue oxygenation;variables for acid-bae balance;amount of fluid administration and transfusion;postoperative laboratory data concerning hepatic and renal functions within the postoperative 30th day	—

Countries

Korea, Republic of

Contacts

Public ContactSanghyun Hong

The Catholic University of Korea, Seoul St. Mary's Hospital

Outcome results